What factors might contribute to a deficiency of folate?
In addition to poor dietary intake of folate itself, deficient intake
of other B vitamins can contribute to folate deficiency. These vitamins
include B1, B2, and B3 which are all involved in folate recycling. Poor
protein intake can cause deficiency of folate binding protein which is
needed for optimal absorption of folate from the intestine, and can
also be related to an insufficient supply of glycine and serine, the
amino acids that directly participate in metabolic recycling of folate.
Excessive intake of alcohol, smoking, and heavy coffee drinking can
also contribute to folate deficiency.
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